We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
VAMP2
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene name

VAMP2

Gene description

Vesicle-associated membrane protein 2 (synaptobrevin 2)

Protein class

FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

Pending cancer tissue analysis.

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable), pancreatic cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis


STAINING SUMMARY

 

GENE INFORMATION

Gene name

VAMP2 (HGNC Symbol)

Synonyms

SYB2, VAMP-2

Description

Vesicle-associated membrane protein 2 (synaptobrevin 2) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

p13.1

Chromosome location (bp)

8159149 - 8163546

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000220205 (version 83.38)

Entrez gene

6844

UniProt

P63027 (UniProt - Evidence at protein level)

neXtProt

NX_P63027

Antibodypedia

VAMP2 antibodies

PROTEIN BROWSER

VAMP2-001
VAMP2-002
VAMP2-003
VAMP2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VAMP2-001
ENSP00000314214
ENST00000316509
P63027 [Direct mapping]
Vesicle-associated membrane protein 2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0000322 [storage vacuole]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005543 [phospholipid binding]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006461 [protein complex assembly]
GO:0006887 [exocytosis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006906 [vesicle fusion]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008021 [synaptic vesicle]
GO:0008022 [protein C-terminus binding]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009749 [response to glucose]
GO:0014047 [glutamate secretion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016192 [vesicle-mediated transport]
GO:0017022 [myosin binding]
GO:0017075 [syntaxin-1 binding]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0017157 [regulation of exocytosis]
GO:0019905 [syntaxin binding]
GO:0030054 [cell junction]
GO:0030136 [clathrin-coated vesicle]
GO:0030141 [secretory granule]
GO:0030667 [secretory granule membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0031201 [SNARE complex]
GO:0031410 [cytoplasmic vesicle]
GO:0031982 [vesicle]
GO:0032403 [protein complex binding]
GO:0032869 [cellular response to insulin stimulus]
GO:0042589 [zymogen granule membrane]
GO:0042802 [identical protein binding]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0043005 [neuron projection]
GO:0043195 [terminal bouton]
GO:0043229 [intracellular organelle]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043308 [eosinophil degranulation]
GO:0043621 [protein self-association]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044306 [neuron projection terminus]
GO:0044325 [ion channel binding]
GO:0045202 [synapse]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050796 [regulation of insulin secretion]
GO:0060203 [clathrin-sculpted glutamate transport vesicle membrane]
GO:0060291 [long-term synaptic potentiation]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0061024 [membrane organization]
GO:0061025 [membrane fusion]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
GO:0070032 [synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex]
GO:0070033 [synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex]
GO:0070044 [synaptobrevin 2-SNAP-25-syntaxin-1a complex]
GO:0070062 [extracellular exosome]
GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane]
GO:0090316 [positive regulation of intracellular protein transport]
GO:1902259 [regulation of delayed rectifier potassium channel activity]
Show all
116 aa
12.7 kDa
No 1
VAMP2-002
ENSP00000466995
ENST00000404970
K7ENK9 [Direct mapping]
Vesicle-associated membrane protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0006906 [vesicle fusion]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
Show all
68 aa
7.8 kDa
No 1
VAMP2-003
ENSP00000418572
ENST00000488857
F8WCA0 [Direct mapping]
Vesicle-associated membrane protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0006906 [vesicle fusion]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
Show all
118 aa
12.9 kDa
No 1
VAMP2-004
ENSP00000467399
ENST00000481878
J3QRU4 [Direct mapping]
Vesicle-associated membrane protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0006906 [vesicle fusion]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
Show all
113 aa
12.3 kDa
No 1

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.