Expression of PSG3 in cancer - Summary - The Human Protein Atlas

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PSG3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PSG3
Gene description	Pregnancy specific beta-1-glycoprotein 3
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enriched (U-2197)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA046327
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046327

GENE INFORMATION
Gene name	PSG3
Synonyms
Description	Pregnancy specific beta-1-glycoprotein 3 (HGNC Symbol)
Entrez gene summary	The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	42721638 - 42740569
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000221826 (version 83.38)
Entrez gene	5671
UniProt	Q16557 (UniProt - Evidence at transcript level)
neXtProt	NX_Q16557
Antibodypedia	PSG3 antibodies

PROTEIN BROWSER

PSG3-001	PSG3-005	PSG3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PSG3-001 ENSP00000332215 ENST00000327495	Q16557 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006952 [defense response] GO:0007565 [female pregnancy] Show all	428 aa 47.9 kDa	Yes	0
PSG3-005 ENSP00000468936 ENST00000595140	M0QX68 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	475 aa 53.9 kDa	Yes	0
PSG3-201 ENSP00000480223 ENST00000614582	Q16557 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006952 [defense response] GO:0007565 [female pregnancy] Show all	428 aa 47.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.