Expression of FANCG in cancer - Summary - The Human Protein Atlas

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FANCG

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FANCG
Gene description	Fanconi anemia, complementation group G
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. CAB008105
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB008105

GENE INFORMATION
Gene name	FANCG (HGNC Symbol)
Synonyms	FAG, XRCC9
Description	Fanconi anemia, complementation group G (HGNC Symbol)
Entrez gene summary	The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	35073835 - 35080016
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000221829 (version 83.38)
Entrez gene	2189
UniProt	O15287 (UniProt - Evidence at protein level)
neXtProt	NX_O15287
Antibodypedia	FANCG antibodies

PROTEIN BROWSER

FANCG-001	FANCG-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FANCG-001 ENSP00000367910 ENST00000378643	O15287 [Direct mapping] Fanconi anemia group G protein Q53XM5 [Target identity:100%; Query identity:100%] Fanconi anemia, complementation group G; Fanconi anemia, complementation group G, isoform CRA_a; cDNA, FLJ93448, Homo sapiens Fanconi anemia, complementation group G (FANCG), mRNA Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000075 [cell cycle checkpoint] GO:0001541 [ovarian follicle development] GO:0003684 [damaged DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006974 [cellular response to DNA damage stimulus] GO:0007005 [mitochondrion organization] GO:0007286 [spermatid development] GO:0009314 [response to radiation] GO:0036297 [interstrand cross-link repair] GO:0043240 [Fanconi anaemia nuclear complex] Show all	622 aa 68.6 kDa	No	0
FANCG-003 ENSP00000409607 ENST00000448890	C9JSE3 [Direct mapping] Fanconi anemia group G protein Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		215 aa 23.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.