Expression of MAGEA3 in cancer - Summary - The Human Protein Atlas

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MAGEA3

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	MAGEA3
Gene description	Melanoma antigen family A3
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (K-562, PC-3, SH-SY5Y, SK-BR-3, U-266/70, U-266/84)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	MAGEA3 (HGNC Symbol)
Synonyms	CT1.3, HIP8, HYPD, MAGE3, MGC14613
Description	Melanoma antigen family A3 (HGNC Symbol)
Entrez gene summary	This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	152698752 - 152702347
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000221867 (version 83.38)
Entrez gene	4102
UniProt	P43357 (UniProt - Evidence at protein level)
neXtProt	NX_P43357
Antibodypedia	MAGEA3 antibodies

PROTEIN BROWSER

MAGEA3-001	MAGEA3-002	MAGEA3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAGEA3-001 ENSP00000359301 ENST00000370278	P43357 [Direct mapping] Melanoma-associated antigen 3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0010955 [negative regulation of protein processing] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0089720 [caspase binding] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] Show all	314 aa 34.7 kDa	No	0
MAGEA3-002 ENSP00000392758 ENST00000417212	E7EMU0 [Direct mapping] Melanoma-associated antigen 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		198 aa 21.5 kDa	No	0
MAGEA3-201 ENSP00000473093 ENST00000598245	P43357 [Direct mapping] Melanoma-associated antigen 3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0010955 [negative regulation of protein processing] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0089720 [caspase binding] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] Show all	314 aa 34.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.