Expression of NPTXR in cancer - Summary - The Human Protein Atlas

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NPTXR

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NPTXR
Gene description	Neuronal pentraxin receptor
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SCLC-21H, U-87 MG)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a subset of neuronal cells in cerebral cortex.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA001079
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and cervical cancer (favourable).
Endometrial cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001079

GENE INFORMATION
Gene name	NPTXR
Synonyms
Description	Neuronal pentraxin receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	38818452 - 38843982
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000221890 (version 83.38)
Entrez gene	23467
UniProt	O95502 (UniProt - Inferred from homology)
neXtProt	NX_O95502
Antibodypedia	NPTXR antibodies

PROTEIN BROWSER

NPTXR-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPTXR-001 ENSP00000327545 ENST00000333039	O95502 [Direct mapping] Neuronal pentraxin receptor Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0046872 [metal ion binding] Show all	500 aa 52.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.