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SLC12A8

GENERAL INFORMATION

Gene name

 SLC12A8

Gene description

 Solute carrier family 12, member 8

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (U-2197)
HPA (normal tissue):Tissue enhanced (thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA031123
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031123

GENE INFORMATION

Gene name

 SLC12A8 (HGNC Symbol)

Synonyms

 CCC9

Description

 Solute carrier family 12, member 8 (HGNC Symbol)

Entrez gene summary

 This gene is thought to be a candidate for psoriasis susceptibility. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2010]

Chromosome

 3

Cytoband

 q21.2

Chromosome location (bp)

 125082636 - 125212864

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000221955 (version 83.38)

Entrez gene

 84561

UniProt

 A0AV02 (UniProt - Evidence at transcript level)

neXtProt

 NX_A0AV02

Antibodypedia

 SLC12A8 antibodies

PROTEIN BROWSER
SLC12A8-001
SLC12A8-003
SLC12A8-004
SLC12A8-014
SLC12A8-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC12A8-001
ENSP00000377112
ENST00000393469
A0AV02 [Direct mapping]
Solute carrier family 12 member 8
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006884 [cell volume homeostasis]
GO:0010107 [potassium ion import]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0022820 [potassium ion symporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 714 aa
78.2 kDa 		No >9
SLC12A8-003
ENSP00000415713
ENST00000430155
A0AV02 [Direct mapping]
Solute carrier family 12 member 8
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006884 [cell volume homeostasis]
GO:0010107 [potassium ion import]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0022820 [potassium ion symporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 515 aa
56.2 kDa 		No 4
SLC12A8-004
ENSP00000418783
ENST00000469902
A0AV02 [Direct mapping]
Solute carrier family 12 member 8
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006884 [cell volume homeostasis]
GO:0010107 [potassium ion import]
GO:0015379 [potassium:chloride symporter activity]
GO:0016020 [membrane]
GO:0022820 [potassium ion symporter activity]
GO:0055064 [chloride ion homeostasis]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 714 aa
78.2 kDa 		No >9
SLC12A8-014
ENSP00000420197
ENST00000479826
H7C5L2 [Direct mapping]
Solute carrier family 12 member 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
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 207 aa
23 kDa 		No 3
SLC12A8-015
ENSP00000418636
ENST00000462437
C9IZN2 [Direct mapping]
Solute carrier family 12 member 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
Show all
 112 aa
11.6 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.