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CCNL2

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GENERAL INFORMATION

Gene name

 CCNL2

Gene description

 Cyclin L2

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Mouse

 Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA053137
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA053137 CACO-2 Nucleoplasm
Vesicles
HPA053137 MCF7 Nucleoplasm
HPA053137 U-2 OS Nucleoplasm

MOUSE CELLS

Main location

 Nucleoplasm

Mouse gene

 ENSMUSG00000029068 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA053137 NIH 3T3 Nucleoplasm

GENE INFORMATION

Gene name

 CCNL2 (HGNC Symbol)

Synonyms

 ania-6b, CCNM, CCNS, HLA-ISO, PCEE, SB138

Description

 Cyclin L2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 1

Cytoband

 p36.33

Chromosome location (bp)

 1385711 - 1399328

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000221978 (version 83.38)

Entrez gene

 81669

UniProt

 Q96S94 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96S94

Antibodypedia

 CCNL2 antibodies

PROTEIN BROWSER
CCNL2-001
CCNL2-002
CCNL2-011
CCNL2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCNL2-001
ENSP00000383611
ENST00000400809
Q96S94 [Direct mapping]
Cyclin-L2
A0A024R072 [Target identity:100%; Query identity:100%]
Cyclin L2, isoform CRA_c
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   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0016607 [nuclear speck]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain]
Show all
 520 aa
58.1 kDa 		Yes 0
CCNL2-002
ENSP00000386158
ENST00000408918
Q96S94 [Direct mapping]
Cyclin-L2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000307 [cyclin-dependent protein kinase holoenzyme complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity]
GO:0016607 [nuclear speck]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:1901409 [positive regulation of phosphorylation of RNA polymerase II C-terminal domain]
Show all
 226 aa
24.6 kDa 		Yes 0
CCNL2-011
ENSP00000464685
ENST00000497013
J3QSH2 [Direct mapping]
Cyclin-L2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019901 [protein kinase binding]
Show all
 86 aa
10.2 kDa 		No 0
CCNL2-201
ENSP00000386132
ENST00000408952
A0A0A0MSF3 [Direct mapping]
Cyclin-L2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019901 [protein kinase binding]
Show all
 347 aa
38.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.