Expression of ZNF630 in cancer - Summary - The Human Protein Atlas

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ZNF630

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZNF630
Gene description	Zinc finger protein 630
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA001053
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001053

GENE INFORMATION
Gene name	ZNF630 (HGNC Symbol)
Synonyms	BC037316, dJ54B20.2, FLJ20573, MGC138344
Description	Zinc finger protein 630 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing an N-terminal Kruppel-associated box-containing (KRAB) domain and 13 Kruppel-type C2H2 zinc finger domains. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	47983356 - 48071658
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000221994 (version 83.38)
Entrez gene	57232
UniProt	Q2M218 (UniProt - Evidence at transcript level)
neXtProt	NX_Q2M218
Antibodypedia	ZNF630 antibodies

PROTEIN BROWSER

ZNF630-001	ZNF630-002	ZNF630-003	ZNF630-005	ZNF630-006	ZNF630-201	ZNF630-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF630-001 ENSP00000386393 ENST00000409324	Q2M218 [Direct mapping] Zinc finger protein 630 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	657 aa 76.1 kDa	No	0
ZNF630-002 ENSP00000354683 ENST00000276054	B2ZWH0 [Direct mapping] HCG1771495, isoform CRA_b; Zinc finger protein 630 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	533 aa 61.6 kDa	No	0
ZNF630-003 ENSP00000407278 ENST00000428686	B2ZWG8 [Direct mapping] Zinc finger protein 630 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	214 aa 25 kDa	No	0
ZNF630-005 ENSP00000408054 ENST00000421903	B2ZWG9 [Direct mapping] Zinc finger protein 630 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	40 aa 4.7 kDa	No	0
ZNF630-006 ENSP00000485938 ENST00000627643	A0A0D9SER6 [Direct mapping] Zinc finger protein 630 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	200 aa 23.4 kDa	No	0
ZNF630-201 ENSP00000393163 ENST00000442455	Q2M218 [Direct mapping] Zinc finger protein 630 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	657 aa 76.1 kDa	No	0
ZNF630-202 ENSP00000480858 ENST00000616492	A0A087WXA8 [Direct mapping] Zinc finger protein 630 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	643 aa 74.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.