Expression of CKMT1A in cancer - Summary

GENERAL INFORMATION
Gene name	CKMT1A
Gene description	Creatine kinase, mitochondrial 1A
Protein class	Enzymes FDA approved drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HaCaT, SCLC-21H, SK-BR-3, T-47d)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several different tissue types, mainly in gastrointestinal tract and squamous epithelium.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA043491
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043491

GENE INFORMATION
Gene name	CKMT1A (HGNC Symbol)
Synonyms	CKMT1
Description	Creatine kinase, mitochondrial 1A (HGNC Symbol)
Entrez gene summary	Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q15.3
Chromosome location (bp)	43692886 - 43699222
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000223572 (version 83.38)
Entrez gene	548596
UniProt	P12532 (UniProt - Evidence at protein level)
neXtProt	NX_P12532
Antibodypedia	CKMT1A antibodies

PROTEIN BROWSER

CKMT1A-001	CKMT1A-002	CKMT1A-003	CKMT1A-004	CKMT1A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CKMT1A-001 ENSP00000413165 ENST00000434505	P12532 [Direct mapping] Creatine kinase U-type, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Show all	GO:0004111 [creatine kinase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006595 [polyamine metabolic process] GO:0006600 [creatine metabolic process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	417 aa 47 kDa	Yes	0
CKMT1A-002 ENSP00000406577 ENST00000413453	P12532 [Direct mapping] Creatine kinase U-type, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Show all	GO:0004111 [creatine kinase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006595 [polyamine metabolic process] GO:0006600 [creatine metabolic process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	417 aa 47 kDa	Yes	0
CKMT1A-003 ENSP00000401927 ENST00000415044	C9JT96 [Direct mapping] Creatine kinase U-type, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005524 [ATP binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] Show all	222 aa 24.6 kDa	Yes	0
CKMT1A-004 ENSP00000398973 ENST00000411750	C9J8F6 [Direct mapping] Creatine kinase U-type, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005524 [ATP binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] Show all	148 aa 16.3 kDa	Yes	0
CKMT1A-201 ENSP00000487331 ENST00000626814	F8WCN3 [Direct mapping] Creatine kinase U-type, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005524 [ATP binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] Show all	298 aa 33.5 kDa	Yes	0