Expression of HBD in cancer - Summary - The Human Protein Atlas

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HBD

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HBD
Gene description	Hemoglobin, delta
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enriched (U-266/70)
HPA (normal tissue):	Tissue enriched (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in erythrocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images. Tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 2 antibodies. HPA043234 , CAB037087
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043234	CAB037087

GENE INFORMATION
Gene name	HBD
Synonyms
Description	Hemoglobin, delta (HGNC Symbol)
Entrez gene summary	The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	5232678 - 5235370
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000223609 (version 83.38)
Entrez gene	3045
UniProt	P02042 (UniProt - Evidence at protein level)
neXtProt	NX_P02042
Antibodypedia	HBD antibodies

PROTEIN BROWSER

HBD-001	HBD-002	HBD-003	HBD-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HBD-001 ENSP00000369654 ENST00000380299	P02042 [Direct mapping] Hemoglobin subunit delta A0N071 [Target identity:100%; Query identity:100%] Delta globin; Delta-globin chain; Hemoglobin delta; Hemoglobin, delta Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005344 [oxygen transporter activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005833 [hemoglobin complex] GO:0007596 [blood coagulation] GO:0015671 [oxygen transport] GO:0019825 [oxygen binding] GO:0020037 [heme binding] GO:0072562 [blood microparticle] Show all	147 aa 16.1 kDa	No	0
HBD-002 ENSP00000414741 ENST00000417377	C9JRG0 [Direct mapping] Hemoglobin subunit delta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005344 [oxygen transporter activity] GO:0015671 [oxygen transport] GO:0016021 [integral component of membrane] GO:0019825 [oxygen binding] GO:0020037 [heme binding] Show all	85 aa 9.8 kDa	No	1
HBD-003 ENSP00000292901 ENST00000292901	E9PFT6 [Direct mapping] Hemoglobin subunit delta Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005344 [oxygen transporter activity] GO:0005506 [iron ion binding] GO:0005833 [hemoglobin complex] GO:0015671 [oxygen transport] GO:0019825 [oxygen binding] GO:0020037 [heme binding] Show all	141 aa 15.4 kDa	No	0
HBD-004 ENSP00000393810 ENST00000429817	E9PEW8 [Direct mapping] Hemoglobin subunit delta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005344 [oxygen transporter activity] GO:0005506 [iron ion binding] GO:0005833 [hemoglobin complex] GO:0015671 [oxygen transport] GO:0019825 [oxygen binding] GO:0020037 [heme binding] Show all	104 aa 11.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.