Cell atlas - CERS1 - The Human Protein Atlas

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CERS1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	CERS1
Gene description	Ceramide synthase 1
Protein class	Disease related genes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Cell line enhanced (HEK 293, AN3-CA)
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA045724
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEK 293, AN3-CA) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA045724	CACO-2	Endoplasmic reticulum
	HPA045724	U-2 OS	Endoplasmic reticulum

GENE INFORMATION
Gene name	CERS1 (HGNC Symbol)
Synonyms	LAG1, LASS1, UOG1
Description	Ceramide synthase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	18868545 - 18896727
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000223802 (version 83.38)
Entrez gene	10715
UniProt	P27544 (UniProt - Evidence at protein level)
neXtProt	NX_P27544
Antibodypedia	CERS1 antibodies

PROTEIN BROWSER

CERS1-001	CERS1-002	CERS1-004	CERS1-005	CERS1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CERS1-001 ENSP00000437648 ENST00000542296	Q5XG75 [Direct mapping] Ceramide synthase 1; LASS1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0050291 [sphingosine N-acyltransferase activity] Show all	239 aa 27.9 kDa	No	6
CERS1-002 ENSP00000389044 ENST00000429504	P27544 [Direct mapping] Ceramide synthase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003674 [molecular_function] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006665 [sphingolipid metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0035690 [cellular response to drug] GO:0036146 [cellular response to mycotoxin] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] GO:0051974 [negative regulation of telomerase activity] GO:0071492 [cellular response to UV-A] GO:0072721 [cellular response to dithiothreitol] Show all	337 aa 38 kDa	No	6
CERS1-004 ENSP00000471428 ENST00000596048	M0R0T2 [Direct mapping] Ceramide synthase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0050291 [sphingosine N-acyltransferase activity] Show all	216 aa 24.7 kDa	No	5
CERS1-005 ENSP00000485308 ENST00000623882	P27544 [Direct mapping] Ceramide synthase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003674 [molecular_function] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006665 [sphingolipid metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0035690 [cellular response to drug] GO:0036146 [cellular response to mycotoxin] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] GO:0051974 [negative regulation of telomerase activity] GO:0071492 [cellular response to UV-A] GO:0072721 [cellular response to dithiothreitol] Show all	350 aa 39.5 kDa	No	7
CERS1-201 ENSP00000485582 ENST00000623927	A0A024R7N8 [Direct mapping] Ceramide synthase 1; HCG2045882, isoform CRA_a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0008083 [growth factor activity] GO:0040007 [growth] GO:0050291 [sphingosine N-acyltransferase activity] Show all	372 aa 39.5 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.