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C4B

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GENERAL INFORMATION

Gene name

 C4B

Gene description

 Complement component 4B (Chido blood group)

Protein class

 Blood group antigen proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (Karpas-707)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Karpas-707)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 C4B (HGNC Symbol)

Synonyms

 C4B1, C4B3, C4F, CH, CO4, CPAMD3

Description

 Complement component 4B (Chido blood group) (HGNC Symbol)

Entrez gene summary

 This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 32014762 - 32035418

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000224389 (version 83.38)

Entrez gene

 721

UniProt

 P0C0L5 (UniProt - Evidence at protein level)

neXtProt

 NX_P0C0L5

Antibodypedia

 C4B antibodies

PROTEIN BROWSER
C4B-001
C4B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
C4B-001
ENSP00000415941
ENST00000435363
P0C0L5 [Direct mapping]
Complement C4-B Complement C4 beta chain Complement C4-B alpha chain C4a anaphylatoxin C4b-B C4d-B Complement C4 gamma chain
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Blood group antigen proteins
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001848 [complement binding]
GO:0004866 [endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0006956 [complement activation]
GO:0006958 [complement activation, classical pathway]
GO:0008228 [opsonization]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0030246 [carbohydrate binding]
GO:0030449 [regulation of complement activation]
GO:0032490 [detection of molecule of bacterial origin]
GO:0044216 [other organism cell]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
GO:2000427 [positive regulation of apoptotic cell clearance]
Show all
 1744 aa
192.7 kDa 		Yes 0
C4B-201
ENSP00000391933
ENST00000425700
F5GXS0 [Direct mapping]
Complement C4-B
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004866 [endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006954 [inflammatory response]
GO:0006956 [complement activation]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
 1698 aa
187.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.