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APOC4-APOC2

GENERAL INFORMATION

Gene name

 APOC4-APOC2

Gene description

 APOC4-APOC2 readthrough (NMD candidate)

Protein class

 Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (Hep G2, HMC-1, THP-1)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Strong positivity in plasma. Also cytoplasmic expression in liver.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 1 antibody.
HPA055877
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA055877

GENE INFORMATION

Gene name

 APOC4-APOC2

Synonyms

Description

 APOC4-APOC2 readthrough (NMD candidate) (HGNC Symbol)

Entrez gene summary

 This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 44942238 - 44949565

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000224916 (version 83.38)

Entrez gene

 344

UniProt

neXtProt

Antibodypedia

 APOC4-APOC2 antibodies

PROTEIN BROWSER
APOC4-APOC2-001
APOC4-APOC2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APOC4-APOC2-001
ENSP00000468139
ENST00000589057
K7ER74 [Direct mapping]
Protein APOC4-APOC2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0006629 [lipid metabolic process]
GO:0006869 [lipid transport]
GO:0008047 [enzyme activator activity]
GO:0042627 [chylomicron]
GO:0043085 [positive regulation of catalytic activity]
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 178 aa
20 kDa 		Yes 1
APOC4-APOC2-201
ENSP00000252490
ENST00000252490
A0A024R0T9 [Direct mapping]
Apolipoprotein C-II, isoform CRA_a; Protein APOC4-APOC2
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0006629 [lipid metabolic process]
GO:0006869 [lipid transport]
GO:0008047 [enzyme activator activity]
GO:0042627 [chylomicron]
GO:0043085 [positive regulation of catalytic activity]
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 101 aa
11.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.