Expression of NOL7 in cancer - Summary - The Human Protein Atlas

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NOL7

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NOL7
Gene description	Nucleolar protein 7, 27kDa
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nucleoli expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA029185
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable).
Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029185

GENE INFORMATION
Gene name	NOL7 (HGNC Symbol)
Synonyms	C6orf90, dJ223E5.2, NOP27, PQBP3, RARG-1
Description	Nucleolar protein 7, 27kDa (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
Chromosome	6
Cytoband	p23
Chromosome location (bp)	13615327 - 13632739
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000225921 (version 83.38)
Entrez gene	51406
UniProt	Q9UMY1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UMY1
Antibodypedia	NOL7 antibodies

PROTEIN BROWSER

NOL7-001	NOL7-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NOL7-001 ENSP00000405674 ENST00000451315	Q9UMY1 [Direct mapping] Nucleolar protein 7 A0A024QZW2 [Target identity:100%; Query identity:100%] Nucleolar protein 7, 27kDa, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0044822 [poly(A) RNA binding] Show all	257 aa 29.4 kDa	No	0
NOL7-002 ENSP00000404836 ENST00000420088	H7C2B1 [Direct mapping] Nucleolar protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		83 aa 9.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.