Expression of MRLN in cancer - Summary - The Human Protein Atlas

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MRLN

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	MRLN
Gene description	Myoregulin
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enriched (RH-30)
HPA (normal tissue):	Tissue enhanced (skeletal muscle)

Protein evidence

Evidence at transcript level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	MRLN (HGNC Symbol)
Synonyms	LINC00948, M1, MLN, MUSER1
Description	Myoregulin (HGNC Symbol)
Entrez gene summary	This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2015]
Chromosome	10
Cytoband	q21.2
Chromosome location (bp)	59736692 - 59756041
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000227877 (version 83.38)
Entrez gene	100507027
UniProt	P0DMT0 (UniProt - Inferred from homology)
neXtProt	NX_P0DMT0
Antibodypedia	MRLN antibodies

PROTEIN BROWSER

MRLN-001	MRLN-002	MRLN-003	MRLN-004	MRLN-005	MRLN-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRLN-001 ENSP00000488748 ENST00000414264	P0DMT0 [Direct mapping] Myoregulin Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004857 [enzyme inhibitor activity] GO:0016021 [integral component of membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0043086 [negative regulation of catalytic activity] GO:1902081 [negative regulation of calcium ion import into sarcoplasmic reticulum] Show all	46 aa 5.2 kDa	No	1
MRLN-002 ENSP00000488299 ENST00000430431	P0DMT0 [Direct mapping] Myoregulin Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004857 [enzyme inhibitor activity] GO:0016021 [integral component of membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0043086 [negative regulation of catalytic activity] GO:1902081 [negative regulation of calcium ion import into sarcoplasmic reticulum] Show all	46 aa 5.2 kDa	No	1
MRLN-003 ENSP00000488584 ENST00000594536	P0DMT0 [Direct mapping] Myoregulin Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004857 [enzyme inhibitor activity] GO:0016021 [integral component of membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0043086 [negative regulation of catalytic activity] GO:1902081 [negative regulation of calcium ion import into sarcoplasmic reticulum] Show all	46 aa 5.2 kDa	No	1
MRLN-004 ENSP00000487738 ENST00000599605		Predicted intracellular proteins Show all		1 aa 0.1 kDa	No	0
MRLN-005 ENSP00000488673 ENST00000602051		Predicted intracellular proteins Show all		1 aa 0.1 kDa	No	0
MRLN-010 ENSP00000488429 ENST00000628562	P0DMT0 [Direct mapping] Myoregulin Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004857 [enzyme inhibitor activity] GO:0016021 [integral component of membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0043086 [negative regulation of catalytic activity] GO:1902081 [negative regulation of calcium ion import into sarcoplasmic reticulum] Show all	46 aa 5.2 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.