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POLR2J2

GENERAL INFORMATION

Gene name

 POLR2J2

Gene description

 Polymerase (RNA) II (DNA directed) polypeptide J2

Protein class

 Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (MOLT-4, U-2 OS)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear or cytoplasmic expression in selected tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 3 antibodies.
HPA042997 , HPA044010 , HPA046970
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042997
HPA044010
HPA046970

GENE INFORMATION

Gene name

 POLR2J2 (HGNC Symbol)

Synonyms

 RPB11b1

Description

 Polymerase (RNA) II (DNA directed) polypeptide J2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 102665368 - 102671629

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000228049 (version 83.38)

Entrez gene

 246721

UniProt

 Q9GZM3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9GZM3

Antibodypedia

 POLR2J2 antibodies

PROTEIN BROWSER
POLR2J2-002
POLR2J2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR2J2-002
ENSP00000351218
ENST00000358438
A6NFM0 [Direct mapping]
DNA-directed RNA polymerase II subunit RPB11-b1
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Predicted intracellular proteins
RNA polymerase related proteins
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GO:0001055 [RNA polymerase II activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
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 158 aa
17.2 kDa 		No 0
POLR2J2-003
ENSP00000330898
ENST00000333432
Q9GZM3 [Direct mapping]
DNA-directed RNA polymerase II subunit RPB11-b1
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Predicted intracellular proteins
RNA polymerase related proteins
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GO:0001055 [RNA polymerase II activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
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 115 aa
13.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.