Expression of PGA4 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PGA4

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PGA4
Gene description	Pepsinogen 4, group I (pepsinogen A)
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Group enriched (BJ hTERT+, THP-1)
HPA (normal tissue):	Tissue enriched (stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in stomach.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 1 antibody. HPA046875
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046875

GENE INFORMATION
Gene name	PGA4
Synonyms
Description	Pepsinogen 4, group I (pepsinogen A) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	61222216 - 61231927
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000229183 (version 83.38)
Entrez gene	643847
UniProt	P0DJD7 (UniProt - Evidence at protein level)
neXtProt	NX_P0DJD7
Antibodypedia	PGA4 antibodies

PROTEIN BROWSER

PGA4-001	PGA4-010	PGA4-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGA4-001 ENSP00000367391 ENST00000378149	P0DJD7 [Direct mapping] Pepsin A-4 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0007586 [digestion] GO:0030163 [protein catabolic process] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0097486 [multivesicular body lumen] Show all	388 aa 42 kDa	Yes	0
PGA4-010 ENSP00000442757 ENST00000537932	F5GXL4 [Direct mapping] Pepsin A-3; Pepsin A-4 Show all	Predicted intracellular proteins Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0030163 [protein catabolic process] Show all	234 aa 24.6 kDa	No	0
PGA4-011 ENSP00000443623 ENST00000544899	F5H0H6 [Direct mapping] Pepsin A-3; Pepsin A-4 Show all	Predicted intracellular proteins Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0030163 [protein catabolic process] Show all	128 aa 13.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.