Expression of MBD3L2 in cancer - Summary - The Human Protein Atlas

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MBD3L2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MBD3L2
Gene description	Methyl-CpG binding domain protein 3-like 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA051259
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051259

GENE INFORMATION
Gene name	MBD3L2
Synonyms
Description	Methyl-CpG binding domain protein 3-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein has been found in germ cell tumors and some somatic tissues. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	7049321 - 7051735
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000230522 (version 83.38)
Entrez gene	125997
UniProt	Q8NHZ7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NHZ7
Antibodypedia	MBD3L2 antibodies

PROTEIN BROWSER

MBD3L2-001	MBD3L2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MBD3L2-001 ENSP00000370800 ENST00000381393	Q8NHZ7 [Direct mapping] Methyl-CpG-binding domain protein 3-like 2 Show all	Predicted intracellular proteins Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005634 [nucleus] GO:0006346 [methylation-dependent chromatin silencing] GO:0008327 [methyl-CpG binding] Show all	208 aa 23 kDa	No	0
MBD3L2-201 ENSP00000480390 ENST00000616171	A0A087WWP0 [Direct mapping] Methyl-CpG-binding domain protein 3-like 2 Show all	Predicted intracellular proteins Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005634 [nucleus] GO:0006346 [methylation-dependent chromatin silencing] GO:0008327 [methyl-CpG binding] Show all	204 aa 22.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.