Tissue expression of PRB4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PRB4
Gene description	Proline-rich protein BstNI subfamily 4
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (salivary gland)
GTEx:	Tissue enhanced (testis)
FANTOM5:	Group enriched (lung, salivary gland)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (salivary gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (lung, salivary gland)

GENE INFORMATION
Gene name	PRB4
Synonyms
Description	Proline-rich protein BstNI subfamily 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the ""Small"" allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]
Chromosome	12
Cytoband	p13.2
Chromosome location (bp)	11307083 - 11310435
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000230657 (version 83.38)
Entrez gene	5545
UniProt
neXtProt
Antibodypedia	PRB4 antibodies

PROTEIN BROWSER

PRB4-001	PRB4-002	PRB4-201	PRB4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRB4-001 ENSP00000442834 ENST00000535904	E9PAL0 [Direct mapping] Basic salivary proline-rich protein 1; Basic salivary proline-rich protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		247 aa 25.1 kDa	Yes	0
PRB4-002 ENSP00000412740 ENST00000445719	E7EXA8 [Direct mapping] Basic salivary proline-rich protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		178 aa 18 kDa	Yes	0
PRB4-201 ENSP00000279575 ENST00000279575	E9PAL0 [Direct mapping] Basic salivary proline-rich protein 1; Basic salivary proline-rich protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		247 aa 25.1 kDa	Yes	0
PRB4-202 ENSP00000481695 ENST00000621732	E7EXA8 [Direct mapping] Basic salivary proline-rich protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		178 aa 18 kDa	Yes	0