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A few cases of malignant lymphomas and lung cancers showed moderate cytoplasmic staining. Remaining malignancies were generally negative.
GENE INFORMATION
Gene name
HLA-DPA1 (HGNC Symbol)
Synonyms
HLA-DP1A
Description
Major histocompatibility complex, class II, DP alpha 1 (HGNC Symbol)
Entrez gene summary
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
P20036 [Direct mapping] HLA class II histocompatibility antigen, DP alpha 1 chain X5CKE2 [Target identity:100%; Query identity:100%] MHC class II antigen; Major histocompatibility complex, class II, DP alpha 1, isoform CRA_a
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0019882 [antigen processing and presentation] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030658 [transport vesicle membrane] GO:0030666 [endocytic vesicle membrane] GO:0030669 [clathrin-coated endocytic vesicle membrane] GO:0031295 [T cell costimulation] GO:0032395 [MHC class II receptor activity] GO:0032588 [trans-Golgi network membrane] GO:0032729 [positive regulation of interferon-gamma production] GO:0042102 [positive regulation of T cell proliferation] GO:0042605 [peptide antigen binding] GO:0042613 [MHC class II protein complex] GO:0050852 [T cell receptor signaling pathway] GO:0050870 [positive regulation of T cell activation] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0071346 [cellular response to interferon-gamma] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
J3KQ99 [Direct mapping] HLA class II histocompatibility antigen, DP alpha 1 chain
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MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014)
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GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0042613 [MHC class II protein complex]