Tissue expression of PRH1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PRH1
Gene description	Proline-rich protein HaeIII subfamily 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (salivary gland)
FANTOM5:	Tissue enriched (salivary gland)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (salivary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (salivary gland)

GENE INFORMATION
Gene name	PRH1 (HGNC Symbol)
Synonyms	Pa
Description	Proline-rich protein HaeIII subfamily 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. Multiple distinct alleles of this locus including the parotid isoelectric-focusing variant slow (PIF-s), the parotid acidic protein (Pa), and the double band slow (Db-s) isoforms have been characterized. The reference genome encodes the Db-s allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Co-transcription of this gene with adjacent genes has been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
Chromosome	12
Cytoband	p13.2
Chromosome location (bp)	10824960 - 11171544
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000231887 (version 83.38)
Entrez gene	5554
UniProt
neXtProt
Antibodypedia	PRH1 antibodies

PROTEIN BROWSER

PRH1-001	PRH1-003	PRH1-004	PRH1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRH1-001 ENSP00000479168 ENST00000543626	A0A087WV42 [Direct mapping] Salivary acidic proline-rich phosphoprotein 1/2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		187 aa 19.1 kDa	Yes	0
PRH1-003 ENSP00000482068 ENST00000539853	A0A087WYT0 [Direct mapping] Salivary acidic proline-rich phosphoprotein 1/2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		175 aa 17.9 kDa	Yes	0
PRH1-004 ENSP00000481761 ENST00000538332	A0A087WYF5 [Direct mapping] Salivary acidic proline-rich phosphoprotein 1/2 Show all	Predicted intracellular proteins Show all		140 aa 14 kDa	No	0
PRH1-201 ENSP00000412436 ENST00000428168	A0A0A0MT31 [Direct mapping] Proline-rich protein 4; Salivary acidic proline-rich phosphoprotein 1/2; Uncharacterized protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		166 aa 17 kDa	Yes	0