Expression of PSG1 in cancer - Summary - The Human Protein Atlas

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PSG1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PSG1
Gene description	Pregnancy specific beta-1-glycoprotein 1
Protein class	CD markers Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (thyroid cancer)
HPA (cell line):	Cell line enriched (U-2197)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA046327
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046327

GENE INFORMATION
Gene name	PSG1 (HGNC Symbol)
Synonyms	CD66f, PBG1, PSBG1, PSGGA
Description	Pregnancy specific beta-1-glycoprotein 1 (HGNC Symbol)
Entrez gene summary	The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	42866464 - 42879822
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000231924 (version 83.38)
Entrez gene	5669
UniProt	P11464 (UniProt - Evidence at protein level)
neXtProt	NX_P11464
Antibodypedia	PSG1 antibodies

PROTEIN BROWSER

PSG1-001	PSG1-002	PSG1-003	PSG1-004	PSG1-006	PSG1-007	PSG1-011	PSG1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PSG1-001 ENSP00000413041 ENST00000436291	P11464 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 1 Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007565 [female pregnancy] Show all	419 aa 47.2 kDa	Yes	0
PSG1-002 ENSP00000244296 ENST00000244296	P11464 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 1 Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007565 [female pregnancy] Show all	426 aa 47.9 kDa	Yes	0
PSG1-003 ENSP00000385386 ENST00000403380	G5E9F7 [Direct mapping] Pregnancy specific beta-1-glycoprotein 1, isoform CRA_a; Pregnancy-specific beta-1-glycoprotein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	326 aa 36.9 kDa	Yes	0
PSG1-004 ENSP00000308970 ENST00000312439	P11464 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 1 Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007565 [female pregnancy] Show all	428 aa 48.1 kDa	Yes	0
PSG1-006 ENSP00000472284 ENST00000595124	M0R235 [Direct mapping] Pregnancy specific beta-1-glycoprotein 1, isoform CRA_e; Pregnancy-specific beta-1-glycoprotein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	324 aa 36.6 kDa	Yes	0
PSG1-007 ENSP00000472610 ENST00000595356	P11464 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 1 Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007565 [female pregnancy] Show all	417 aa 46.9 kDa	Yes	0
PSG1-011 ENSP00000469575 ENST00000595930	M0QY44 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	154 aa 17.2 kDa	No	0
PSG1-012 ENSP00000470690 ENST00000597058	M0QZQ1 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	242 aa 26.7 kDa	No	0

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The Human Protein Atlas

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