Expression of TMEM114 in cancer - Summary - The Human Protein Atlas

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TMEM114

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	TMEM114
Gene description	Transmembrane protein 114
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (seminal vesicle)

Protein evidence

Evidence at transcript level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	TMEM114
Synonyms
Description	Transmembrane protein 114 (HGNC Symbol)
Entrez gene summary	This gene encodes a glycosylated transmembrane protein that plays a role in lens and eye development. Mutations in this gene, including a t(16;22)(p13.3;q11.2) translocation, are associated with congenital and juvenile cataract disorders. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Chromosome	16
Cytoband	p13.2
Chromosome location (bp)	8537605 - 8590193
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000232258 (version 83.38)
Entrez gene	283953
UniProt	B3SHH9 (UniProt - Evidence at transcript level)
neXtProt	NX_B3SHH9
Antibodypedia	TMEM114 antibodies

PROTEIN BROWSER

TMEM114-001	TMEM114-003	TMEM114-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM114-001 ENSP00000484263 ENST00000620492	B3SHH9 [Direct mapping] Transmembrane protein 114 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Show all	GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0016327 [apicolateral plasma membrane] Show all	223 aa 24.2 kDa	Yes	3
TMEM114-003 ENSP00000485294 ENST00000624696	A0A096LNY9 [Direct mapping] Transmembrane protein 114 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	177 aa 19.2 kDa	No	2
TMEM114-004 ENSP00000454261 ENST00000568335	H3BM71 [Direct mapping] HCG15406; Transmembrane protein 114 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	142 aa 15.6 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.