Tissue expression of HLA-DQB2 - Summary

GENERAL INFORMATION
Gene name	HLA-DQB2
Gene description	Major histocompatibility complex, class II, DQ beta 2
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lung, skin)
GTEx:	Tissue enhanced (skin)
FANTOM5:	Tissue enhanced (lung, tonsil)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, skin)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skin)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, tonsil)

GENE INFORMATION
Gene name	HLA-DQB2 (HGNC Symbol)
Synonyms	HLA-DXB
Description	Major histocompatibility complex, class II, DQ beta 2 (HGNC Symbol)
Entrez gene summary	HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus. [provided by RefSeq, Oct 2010]
Chromosome	6
Cytoband	p21.32
Chromosome location (bp)	32756098 - 32763534
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000232629 (version 83.38)
Entrez gene	3120
UniProt	P05538 (UniProt - Evidence at protein level)
neXtProt	NX_P05538
Antibodypedia	HLA-DQB2 antibodies

PROTEIN BROWSER

HLA-DQB2-001	HLA-DQB2-002	HLA-DQB2-003	HLA-DQB2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HLA-DQB2-001 ENSP00000410512 ENST00000435145	A2ADX3 [Direct mapping] HLA class II histocompatibility antigen, DQ beta 2 chain; cDNA FLJ40688 fis, clone THYMU2024185, highly similar to HLA class II histocompatibility antigen, DX beta chain Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0042613 [MHC class II protein complex] Show all	275 aa 30.9 kDa	Yes	1
HLA-DQB2-002 ENSP00000390431 ENST00000411527	P05538 [Direct mapping] HLA class II histocompatibility antigen, DQ beta 2 chain Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0010008 [endosome membrane] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0019882 [antigen processing and presentation] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030658 [transport vesicle membrane] GO:0030666 [endocytic vesicle membrane] GO:0030669 [clathrin-coated endocytic vesicle membrane] GO:0031295 [T cell costimulation] GO:0032395 [MHC class II receptor activity] GO:0032588 [trans-Golgi network membrane] GO:0042613 [MHC class II protein complex] GO:0050852 [T cell receptor signaling pathway] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] Show all	227 aa 26 kDa	Yes	0
HLA-DQB2-003 ENSP00000396330 ENST00000437316	Q5SR05 [Direct mapping] HLA class II histocompatibility antigen, DQ beta 2 chain Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0042613 [MHC class II protein complex] Show all	264 aa 29.9 kDa	Yes	1
HLA-DQB2-004 ENSP00000415997 ENST00000427449	H0Y7Y7 [Direct mapping] HLA class II histocompatibility antigen, DQ beta 2 chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0042613 [MHC class II protein complex] Show all	218 aa 25.1 kDa	Yes	0