Expression of PET117 in cancer - Summary - The Human Protein Atlas

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PET117

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PET117
Gene description	PET117 homolog
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA047716
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047716

GENE INFORMATION
Gene name	PET117
Synonyms
Description	PET117 homolog (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	p11.23
Chromosome location (bp)	18137873 - 18143169
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000232838 (version 83.38)
Entrez gene	100303755
UniProt	Q6UWS5 (UniProt - Inferred from homology)
neXtProt	NX_Q6UWS5
Antibodypedia	PET117 antibodies

PROTEIN BROWSER

PET117-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PET117-001 ENSP00000397881 ENST00000432901	Q6UWS5 [Direct mapping] Protein PET117 homolog, mitochondrial L0R6F6 [Target identity:100%; Query identity:100%] Alternative protein CSRP2BP Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] Show all	81 aa 9.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.