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Most cancer tissues showed weak to moderate cytoplasmic immunoreactivity. Strong staining was observed in a single case of papillary adenocarcinoma of thyroid and few cases of ovarian cancers were strongly stained. Several squamous and basal cell carcinomas and several gliomas, stomach, liver and urothelial cancers were negative.
This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Oxidoreductases Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000302 [response to reactive oxygen species] GO:0001659 [temperature homeostasis] GO:0001885 [endothelial cell development] GO:0002862 [negative regulation of inflammatory response to antigenic stimulus] GO:0004602 [glutathione peroxidase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006195 [purine nucleotide catabolic process] GO:0006629 [lipid metabolic process] GO:0006641 [triglyceride metabolic process] GO:0006749 [glutathione metabolic process] GO:0006915 [apoptotic process] GO:0006979 [response to oxidative stress] GO:0007605 [sensory perception of sound] GO:0008283 [cell proliferation] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0009410 [response to xenobiotic stimulus] GO:0009609 [response to symbiotic bacterium] GO:0009611 [response to wounding] GO:0009636 [response to toxic substance] GO:0009650 [UV protection] GO:0010269 [response to selenium ion] GO:0010332 [response to gamma radiation] GO:0014902 [myotube differentiation] GO:0017124 [SH3 domain binding] GO:0018158 [protein oxidation] GO:0019369 [arachidonic acid metabolic process] GO:0019372 [lipoxygenase pathway] GO:0033194 [response to hydroperoxide] GO:0033599 [regulation of mammary gland epithelial cell proliferation] GO:0034599 [cellular response to oxidative stress] GO:0040029 [regulation of gene expression, epigenetic] GO:0042311 [vasodilation] GO:0042542 [response to hydrogen peroxide] GO:0042744 [hydrogen peroxide catabolic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043403 [skeletal muscle tissue regeneration] GO:0043523 [regulation of neuron apoptotic process] GO:0043534 [blood vessel endothelial cell migration] GO:0044281 [small molecule metabolic process] GO:0045444 [fat cell differentiation] GO:0045454 [cell redox homeostasis] GO:0048741 [skeletal muscle fiber development] GO:0051450 [myoblast proliferation] GO:0051702 [interaction with symbiont] GO:0051897 [positive regulation of protein kinase B signaling] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0060047 [heart contraction] GO:0060055 [angiogenesis involved in wound healing] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0070062 [extracellular exosome] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0097413 [Lewy body] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1902905 [positive regulation of fibril organization]
Enzymes ENZYME proteins Oxidoreductases Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species] GO:0004602 [glutathione peroxidase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006195 [purine nucleotide catabolic process] GO:0006749 [glutathione metabolic process] GO:0006979 [response to oxidative stress] GO:0009650 [UV protection] GO:0010269 [response to selenium ion] GO:0017124 [SH3 domain binding] GO:0019369 [arachidonic acid metabolic process] GO:0019372 [lipoxygenase pathway] GO:0033599 [regulation of mammary gland epithelial cell proliferation] GO:0034599 [cellular response to oxidative stress] GO:0040029 [regulation of gene expression, epigenetic] GO:0042542 [response to hydrogen peroxide] GO:0042744 [hydrogen peroxide catabolic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044281 [small molecule metabolic process] GO:0045454 [cell redox homeostasis] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0060047 [heart contraction] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0070062 [extracellular exosome] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0097413 [Lewy body] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902905 [positive regulation of fibril organization]