Fields »
ABOUT
HELP
BLOG
TWIST2

GENERAL INFORMATION

Gene name

 TWIST2

Gene description

 Twist family bHLH transcription factor 2

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (BJ, BJ hTERT+, BJ hTERT+ SV40 Large T+ RasG12V, U-2197)
HPA (normal tissue):Tissue enhanced (cervix, uterine)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TWIST2 (HGNC Symbol)

Synonyms

 bHLHa39, Dermo-1, DERMO1

Description

 Twist family bHLH transcription factor 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 238848032 - 238910543

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000233608 (version 83.38)

Entrez gene

 117581

UniProt

 Q8WVJ9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WVJ9

Antibodypedia

 TWIST2 antibodies

PROTEIN BROWSER
TWIST2-001
TWIST2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TWIST2-001
ENSP00000405176
ENST00000448943
Q8WVJ9 [Direct mapping]
Twist-related protein 2
A0A024R4D4 [Target identity:100%; Query identity:100%]
Twist homolog 2 (Drosophila), isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 160 aa
18.1 kDa 		No 0
TWIST2-201
ENSP00000482581
ENST00000612363
Q8WVJ9 [Direct mapping]
Twist-related protein 2
A0A024R4D4 [Target identity:100%; Query identity:100%]
Twist homolog 2 (Drosophila), isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding]
GO:0001649 [osteoblast differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008285 [negative regulation of cell proliferation]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0019904 [protein domain specific binding]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0043066 [negative regulation of apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0044092 [negative regulation of molecular function]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0060325 [face morphogenesis]
GO:0061303 [cornea development in camera-type eye]
Show all
 160 aa
18.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.