Expression of PIRT in cancer - Summary - The Human Protein Atlas

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PIRT

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PIRT
Gene description	Phosphoinositide-interacting regulator of transient receptor potential channels
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (adrenal gland, cerebral cortex, rectum)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Low expression in CNS, renal tubules and hepatocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. External characterization data supports antibody staining.
Reliability score	Uncertain based on 1 antibody. HPA042337
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042337

GENE INFORMATION
Gene name	PIRT
Synonyms
Description	Phosphoinositide-interacting regulator of transient receptor potential channels (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p12
Chromosome location (bp)	10822475 - 10838445
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000233670 (version 83.38)
Entrez gene	644139
UniProt	P0C851 (UniProt - Evidence at transcript level)
neXtProt	NX_P0C851
Antibodypedia	PIRT antibodies

PROTEIN BROWSER

PIRT-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIRT-001 ENSP00000462046 ENST00000580256	P0C851 [Direct mapping] Phosphoinositide-interacting protein Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	137 aa 15.3 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.