Cell atlas - JRK - The Human Protein Atlas

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JRK

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	JRK
Gene description	Jrk helix-turn-helix protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nucleoli & nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Nucleoli (approved), Nuclear bodies (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA052675
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nucleoli & nuclear bodies.

Main location

Nucleus (approved)

Additional location

Nucleoli (approved), Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA052675	HeLa	Nucleus
	HPA052675	SiHa	Nucleus
			Nucleoli	Intensity
			Nuclear bodies	Intensity
	HPA052675	U-2 OS	Nucleus
	HPA052675	U-2 OS	Nucleoli	Intensity

GENE INFORMATION
Gene name	JRK (HGNC Symbol)
Synonyms	jerky, JH8
Description	Jrk helix-turn-helix protein (HGNC Symbol)
Entrez gene summary	This gene encodes a conserved protein that is similar to DNA-binding proteins, such as major centromere autoantigen B (CENPB). Inactivation of the related gene in mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	142657460 - 142681968
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000234616 (version 83.38)
Entrez gene	8629
UniProt
neXtProt
Antibodypedia	JRK antibodies

PROTEIN BROWSER

JRK-001	JRK-003	JRK-007	JRK-008	JRK-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
JRK-001 ENSP00000461610 ENST00000571961	D3DWI5 [Direct mapping] Jerky homolog (Mouse), isoform CRA_b; Jerky protein homolog Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] Show all	556 aa 61.8 kDa	No	0
JRK-003 ENSP00000485390 ENST00000614134	Q86XJ5 [Direct mapping] JRK protein; Jerky homolog (Mouse), isoform CRA_a; Jerky protein homolog Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] Show all	568 aa 62.8 kDa	No	0
JRK-007 ENSP00000483808 ENST00000615982	D3DWI5 [Direct mapping] Jerky homolog (Mouse), isoform CRA_b; Jerky protein homolog Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] Show all	556 aa 61.8 kDa	No	0
JRK-008 ENSP00000482585 ENST00000503272	A0A087WZD9 [Direct mapping] Jerky protein homolog Show all	Predicted intracellular proteins Show all		25 aa 2.8 kDa	No	0
JRK-201 ENSP00000482410 ENST00000612905	Q86XJ5 [Direct mapping] JRK protein; Jerky homolog (Mouse), isoform CRA_a; Jerky protein homolog Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003729 [mRNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0030529 [ribonucleoprotein complex] Show all	568 aa 62.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.