Expression of ARHGEF38 in cancer - Summary

GENERAL INFORMATION
Gene name	ARHGEF38
Gene description	Rho guanine nucleotide exchange factor (GEF) 38
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (prostate cancer)
HPA (cell line):	Group enriched (RPTEC TERT1, SK-BR-3, T-47d)
HPA (normal tissue):	Tissue enhanced (breast)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in a subset of cells in prostate, and gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA036510
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA036510

GENE INFORMATION
Gene name	ARHGEF38 (HGNC Symbol)
Synonyms	FLJ20184
Description	Rho guanine nucleotide exchange factor (GEF) 38 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q24
Chromosome location (bp)	105552620 - 105708093
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000236699 (version 83.38)
Entrez gene	54848
UniProt	Q9NXL2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NXL2
Antibodypedia	ARHGEF38 antibodies

PROTEIN BROWSER

ARHGEF38-001	ARHGEF38-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGEF38-001 ENSP00000416125 ENST00000420470	Q9NXL2 [Direct mapping] Rho guanine nucleotide exchange factor 38 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	777 aa 89.1 kDa	No	0
ARHGEF38-004 ENSP00000265154 ENST00000265154	Q9NXL2 [Direct mapping] Rho guanine nucleotide exchange factor 38 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005737 [cytoplasm] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	219 aa 25.5 kDa	No	0