Expression of PATE4 in cancer - Summary - The Human Protein Atlas

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PATE4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PATE4
Gene description	Prostate and testis expressed 4
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (seminal vesicle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in sperm acrosomes in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External characterization data supports antibody staining.
Reliability score	Approved based on 1 antibody. HPA045632
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045632

GENE INFORMATION
Gene name	PATE4 (HGNC Symbol)
Synonyms	FLJ41047, PATE-B
Description	Prostate and testis expressed 4 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q24.2
Chromosome location (bp)	125833316 - 125840069
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000237353 (version 83.38)
Entrez gene	399968
UniProt	P0C8F1 (UniProt - Evidence at transcript level)
neXtProt	NX_P0C8F1
Antibodypedia	PATE4 antibodies

PROTEIN BROWSER

PATE4-001	PATE4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PATE4-001 ENSP00000411439 ENST00000457514	P0C8F1 [Direct mapping] Prostate and testis expressed protein 4 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0009611 [response to wounding] GO:0050804 [modulation of synaptic transmission] Show all	98 aa 11.4 kDa	Yes	0
PATE4-003 ENSP00000435472 ENST00000534411	E9PK74 [Direct mapping] Prostate and testis-expressed protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		59 aa 7.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.