Expression of RGL2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

RGL2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RGL2
Gene description	Ral guanine nucleotide dissociation stimulator-like 2
Protein class	Plasma proteins Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA053444
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA053444

GENE INFORMATION
Gene name	RGL2 (HGNC Symbol)
Synonyms	HKE1.5, KE1.5, RAB2L
Description	Ral guanine nucleotide dissociation stimulator-like 2 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p21.32
Chromosome location (bp)	33291654 - 33299324
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000237441 (version 83.38)
Entrez gene	5863
UniProt	O15211 (UniProt - Evidence at protein level)
neXtProt	NX_O15211
Antibodypedia	RGL2 antibodies

PROTEIN BROWSER

RGL2-001	RGL2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RGL2-001 ENSP00000420211 ENST00000497454	O15211 [Direct mapping] Ral guanine nucleotide dissociation stimulator-like 2 A0A024RCS9 [Target identity:100%; Query identity:100%] Ral guanine nucleotide dissociation stimulator-like 2, isoform CRA_b Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005088 [Ras guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	777 aa 83.5 kDa	No	0
RGL2-009 ENSP00000392918 ENST00000425946	A2AB89 [Direct mapping] Ral guanine nucleotide dissociation stimulator-like 2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		146 aa 15.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.