Expression of AMY1A in cancer - Summary

GENERAL INFORMATION
Gene name	AMY1A
Gene description	Amylase, alpha 1A (salivary)
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in salivary gland and pancreatic exocrine glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 4 antibodies. HPA045394 , HPA045399 , HPA046980 , CAB004310
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

STAINING SUMMARY

HPA045394	HPA045399	HPA046980	CAB004310

GENE INFORMATION
Gene name	AMY1A (HGNC Symbol)
Synonyms	AMY1
Description	Amylase, alpha 1A (salivary) (HGNC Symbol)
Entrez gene summary	Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p21.1
Chromosome location (bp)	103655290 - 103664554
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000237763 (version 83.38)
Entrez gene	276
UniProt	P04745 (UniProt - Evidence at protein level)
neXtProt	NX_P04745
Antibodypedia	AMY1A antibodies

PROTEIN BROWSER

AMY1A-001	AMY1A-002	AMY1A-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMY1A-001 ENSP00000359100 ENST00000370083	P04745 [Direct mapping] Alpha-amylase 1 Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003824 [catalytic activity] GO:0004556 [alpha-amylase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0007586 [digestion] GO:0043169 [cation binding] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	511 aa 57.8 kDa	Yes	0
AMY1A-002 ENSP00000399836 ENST00000430659	Q5T085 [Direct mapping] Alpha-amylase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003824 [catalytic activity] GO:0004556 [alpha-amylase activity] GO:0005975 [carbohydrate metabolic process] GO:0043169 [cation binding] Show all	226 aa 25.6 kDa	Yes	0
AMY1A-003 ENSP00000408386 ENST00000422549	Q5T084 [Direct mapping] Alpha-amylase 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] Show all	105 aa 12.4 kDa	Yes	0