Expression of OR2W3 in cancer - Summary - The Human Protein Atlas

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OR2W3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OR2W3
Gene description	Olfactory receptor, family 2, subfamily W, member 3
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (thyroid cancer)
HPA (cell line):	Cell line enhanced (HEL, PC-3, U-2 OS, WM-115)
HPA (normal tissue):	Tissue enhanced (bone marrow, thyroid gland)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA045594
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045594

GENE INFORMATION
Gene name	OR2W3 (HGNC Symbol)
Synonyms	OR2W3P, OR2W8P, OST718
Description	Olfactory receptor, family 2, subfamily W, member 3 (HGNC Symbol)
Entrez gene summary	Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q44
Chromosome location (bp)	247895587 - 247896531
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000238243 (version 83.38)
Entrez gene	343171
UniProt	Q7Z3T1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q7Z3T1
Antibodypedia	OR2W3 antibodies

PROTEIN BROWSER

OR2W3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OR2W3-001 ENSP00000353516 ENST00000360358	Q7Z3T1 [Direct mapping] Olfactory receptor 2W3 Show all	G-protein coupled receptors Odorant/olfactory and gustatory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004984 [olfactory receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007608 [sensory perception of smell] GO:0016021 [integral component of membrane] GO:0050911 [detection of chemical stimulus involved in sensory perception of smell] Show all	314 aa 34.8 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.