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RBM14

GENERAL INFORMATION

Gene name

 RBM14

Gene description

 RNA binding motif protein 14

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA006628
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and pancreatic cancer (favourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006628

GENE INFORMATION

Gene name

 RBM14 (HGNC Symbol)

Synonyms

 COAA, DKFZp779J0927, SIP, SYTIP1

Description

 RNA binding motif protein 14 (HGNC Symbol)

Entrez gene summary

 This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 66616582 - 66627347

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000239306 (version 83.38)

Entrez gene

 10432

UniProt

 Q96PK6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96PK6

Antibodypedia

 RBM14 antibodies

PROTEIN BROWSER
RBM14-001
RBM14-002
RBM14-003
RBM14-004
RBM14-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBM14-001
ENSP00000311747
ENST00000310137
Q96PK6 [Direct mapping]
RNA-binding protein 14
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006351 [transcription, DNA-templated]
GO:0009725 [response to hormone]
GO:0016575 [histone deacetylation]
GO:0016592 [mediator complex]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0030529 [ribonucleoprotein complex]
GO:0030674 [protein binding, bridging]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046600 [negative regulation of centriole replication]
GO:0060395 [SMAD protein signal transduction]
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 669 aa
69.5 kDa 		No 0
RBM14-002
ENSP00000377548
ENST00000393979
Q96PK6 [Direct mapping]
RNA-binding protein 14
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006351 [transcription, DNA-templated]
GO:0009725 [response to hormone]
GO:0016575 [histone deacetylation]
GO:0016592 [mediator complex]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0030529 [ribonucleoprotein complex]
GO:0030674 [protein binding, bridging]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046600 [negative regulation of centriole replication]
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 156 aa
17.1 kDa 		No 0
RBM14-003
ENSP00000386518
ENST00000409372
B8ZZ74 [Direct mapping]
RNA-binding protein 14
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   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 159 aa
17.7 kDa 		No 0
RBM14-004
ENSP00000414650
ENST00000443702
F8WDX3 [Direct mapping]
RNA-binding protein 14
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 129 aa
14.2 kDa 		No 0
RBM14-014
ENSP00000386995
ENST00000409738
Q96PK6 [Direct mapping]
RNA-binding protein 14
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0006351 [transcription, DNA-templated]
GO:0009725 [response to hormone]
GO:0016575 [histone deacetylation]
GO:0016592 [mediator complex]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0030529 [ribonucleoprotein complex]
GO:0030674 [protein binding, bridging]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046600 [negative regulation of centriole replication]
Show all
 119 aa
13 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.