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TLR9

GENERAL INFORMATION

Gene name

 TLR9

Gene description

 Toll-like receptor 9

Protein class

 CD markers
FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node)

GENE INFORMATION

Gene name

 TLR9 (HGNC Symbol)

Synonyms

 CD289

Description

 Toll-like receptor 9 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p21.2

Chromosome location (bp)

 52221080 - 52226163

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000239732 (version 83.38)

Entrez gene

 54106

UniProt

 Q9NR96 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NR96

Antibodypedia

 TLR9 antibodies

PROTEIN BROWSER
TLR9-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TLR9-001
ENSP00000353874
ENST00000360658
Q9NR96 [Direct mapping]
Toll-like receptor 9
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002237 [response to molecule of bacterial origin]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007252 [I-kappaB phosphorylation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0010628 [positive regulation of gene expression]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030277 [maintenance of gastrointestinal epithelium]
GO:0032009 [early phagosome]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032640 [tumor necrosis factor production]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032717 [negative regulation of interleukin-8 production]
GO:0032722 [positive regulation of chemokine production]
GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032733 [positive regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032741 [positive regulation of interleukin-18 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034122 [negative regulation of toll-like receptor signaling pathway]
GO:0034123 [positive regulation of toll-like receptor signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0035197 [siRNA binding]
GO:0036020 [endolysosome membrane]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0042742 [defense response to bacterium]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0045078 [positive regulation of interferon-gamma biosynthetic process]
GO:0045087 [innate immune response]
GO:0045356 [positive regulation of interferon-alpha biosynthetic process]
GO:0045359 [positive regulation of interferon-beta biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0050707 [regulation of cytokine secretion]
GO:0050729 [positive regulation of inflammatory response]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051770 [positive regulation of nitric-oxide synthase biosynthetic process]
GO:1901895 [negative regulation of calcium-transporting ATPase activity]
Show all
 1032 aa
115.9 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.