Expression of WBP1 in cancer - Summary - The Human Protein Atlas

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WBP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	WBP1
Gene description	WW domain binding protein 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquiotus cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA057067
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable), urothelial cancer (favourable) and pancreatic cancer (favourable).
Colorectal cancer p<0.001 Urothelial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA057067

GENE INFORMATION
Gene name	WBP1 (HGNC Symbol)
Synonyms	WBP-1
Description	WW domain binding protein 1 (HGNC Symbol)
Entrez gene summary	The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Chromosome	2
Cytoband	p13.1
Chromosome location (bp)	74458329 - 74460891
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000239779 (version 83.38)
Entrez gene	23559
UniProt	Q96G27 (UniProt - Evidence at protein level)
neXtProt	NX_Q96G27
Antibodypedia	WBP1 antibodies

PROTEIN BROWSER

WBP1-001	WBP1-002	WBP1-004	WBP1-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WBP1-001 ENSP00000233615 ENST00000233615	Q96G27 [Direct mapping] WW domain-binding protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0050699 [WW domain binding] Show all	269 aa 29.1 kDa	No	1
WBP1-002 ENSP00000377542 ENST00000393972	A8MX15 [Direct mapping] HCG2039828, isoform CRA_g; WW domain-binding protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	303 aa 32.8 kDa	No	1
WBP1-004 ENSP00000386812 ENST00000409737	B8ZZ95 [Direct mapping] WW domain-binding protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	266 aa 28.7 kDa	No	1
WBP1-015 ENSP00000408816 ENST00000428943	C9JLM6 [Direct mapping] WW domain-binding protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	250 aa 27.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.