Tissue expression of AMY2B - Summary - The Human Protein Atlas

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AMY2B

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	AMY2B
Gene description	Amylase, alpha 2B (pancreatic)
Protein class	Enzymes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (pancreas)
GTEx:	Tissue enriched (pancreas)
FANTOM5:	Tissue enriched (salivary gland)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in pancreatic exocrine glandular cells and salivary gland.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 3 antibodies. HPA045394 , HPA045399 , HPA046980
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pancreas)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pancreas)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (salivary gland)

GENE INFORMATION
Gene name	AMY2B (HGNC Symbol)
Synonyms	AMY2
Description	Amylase, alpha 2B (pancreatic) (HGNC Symbol)
Entrez gene summary	Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jun 2013]
Chromosome	1
Cytoband	p21.1
Chromosome location (bp)	103553815 - 103579534
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000240038 (version 83.38)
Entrez gene	280
UniProt	P19961 (UniProt - Evidence at protein level)
neXtProt	NX_P19961
Antibodypedia	AMY2B antibodies

PROTEIN BROWSER

AMY2B-001	AMY2B-004	AMY2B-005	AMY2B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMY2B-001 ENSP00000354610 ENST00000361355	P19961 [Direct mapping] Alpha-amylase 2B Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004556 [alpha-amylase activity] GO:0005975 [carbohydrate metabolic process] GO:0007586 [digestion] GO:0043169 [cation binding] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	511 aa 57.7 kDa	Yes	0
AMY2B-004 ENSP00000391423 ENST00000435302	C9J2Z5 [Direct mapping] Alpha-amylase 2B Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] Show all	96 aa 11.4 kDa	Yes	0
AMY2B-005 ENSP00000401627 ENST00000453959	C9JWK7 [Direct mapping] Alpha-amylase 2B Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] Show all	86 aa 10.2 kDa	Yes	0
AMY2B-201 ENSP00000481588 ENST00000610648	P19961 [Direct mapping] Alpha-amylase 2B Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004556 [alpha-amylase activity] GO:0005975 [carbohydrate metabolic process] GO:0007586 [digestion] GO:0043169 [cation binding] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	511 aa 57.7 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.