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Cytoplasmic expression in subsets of immune cells in several tissues.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images.
A single case of malignant melanoma displayed strong cytoplasmic staining. Fraction of cells in rare cases of endometrial and stomach cancers showed weak to moderate positivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
LY6G5B (HGNC Symbol)
Synonyms
C6orf19, G5b
Description
Lymphocyte antigen 6 complex, locus G5B (HGNC Symbol)
Entrez gene summary
LY6G5B belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]