Expression of PCDHGC3 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PCDHGC3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PCDHGC3
Gene description	Protocadherin gamma subfamily C, 3
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, melanoma)
HPA (cell line):	Cell line enhanced (U-138 MG, WM-115)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA008755
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable), ovarian cancer (unfavourable) and renal cancer (unfavourable).
Urothelial cancer p<0.001 Ovarian cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008755

GENE INFORMATION
Gene name	PCDHGC3 (HGNC Symbol)
Synonyms	PC-43, PC43, PCDH-GAMMA-C3, PCDH2
Description	Protocadherin gamma subfamily C, 3 (HGNC Symbol)
Entrez gene summary	This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	141475947 - 141512979
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000240184 (version 83.38)
Entrez gene	5098
UniProt	Q9UN70 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UN70
Antibodypedia	PCDHGC3 antibodies

PROTEIN BROWSER

PCDHGC3-001	PCDHGC3-002	PCDHGC3-003	PCDHGC3-005	PCDHGC3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCDHGC3-001 ENSP00000312070 ENST00000308177	Q9UN70 [Direct mapping] Protocadherin gamma-C3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0050808 [synapse organization] GO:0070062 [extracellular exosome] Show all	934 aa 101.1 kDa	No	1
PCDHGC3-002 ENSP00000483383 ENST00000617641	Q9BR81 [Direct mapping] Protocadherin gamma subfamily C, 3; Protocadherin gamma-C3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007155 [cell adhesion] Show all	134 aa 14.1 kDa	No	0
PCDHGC3-003 ENSP00000481219 ENST00000611950	Q9UN70 [Direct mapping] Protocadherin gamma-C3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016339 [calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0070062 [extracellular exosome] Show all	863 aa 94.5 kDa	No	2
PCDHGC3-005 ENSP00000484352 ENST00000621008	A0A087X1P2 [Direct mapping] Protocadherin gamma-C3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] Show all	242 aa 26.5 kDa	No	0
PCDHGC3-006 ENSP00000481673 ENST00000617222	A0A087WYB5 [Direct mapping] Protocadherin gamma-C3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007155 [cell adhesion] Show all	185 aa 19.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.