Expression of COX19 in cancer - Summary - The Human Protein Atlas

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COX19

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	COX19
Gene description	COX19 cytochrome c oxidase assembly factor
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA021226
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021226

GENE INFORMATION
Gene name	COX19 (HGNC Symbol)
Synonyms	MGC104475
Description	COX19 cytochrome c oxidase assembly factor (HGNC Symbol)
Entrez gene summary	COX19 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox19 protein may play a role in metal transport to the mitochondrial intermembrane space and assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008]
Chromosome	7
Cytoband	p22.3
Chromosome location (bp)	898778 - 975599
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000240230 (version 83.38)
Entrez gene	90639
UniProt	Q49B96 (UniProt - Evidence at protein level)
neXtProt	NX_Q49B96
Antibodypedia	COX19 antibodies

PROTEIN BROWSER

COX19-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COX19-001 ENSP00000342015 ENST00000344111	Q49B96 [Direct mapping] Cytochrome c oxidase assembly protein COX19 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005758 [mitochondrial intermembrane space] GO:0005829 [cytosol] GO:0009060 [aerobic respiration] GO:0033617 [mitochondrial respiratory chain complex IV assembly] Show all	90 aa 10.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.