Expression of ACAD11 in cancer - Summary

GENERAL INFORMATION
Gene name	ACAD11
Gene description	Acyl-CoA dehydrogenase family, member 11
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (renal cancer)
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in selected tissues, most abundant in brain, kidney and liver.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA048317
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA048317

GENE INFORMATION
Gene name	ACAD11 (HGNC Symbol)
Synonyms	FLJ12592
Description	Acyl-CoA dehydrogenase family, member 11 (HGNC Symbol)
Entrez gene summary	This gene encodes an acyl-CoA dehydrogenase enzyme with a preference for carbon chain lengths between 20 and 26. Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene. [provided by RefSeq, Aug 2015]
Chromosome	3
Cytoband	q22.1
Chromosome location (bp)	132558138 - 132660723
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000240303 (version 83.38)
Entrez gene	84129
UniProt	Q709F0 (UniProt - Evidence at protein level)
neXtProt	NX_Q709F0
Antibodypedia	ACAD11 antibodies

PROTEIN BROWSER

ACAD11-001	ACAD11-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACAD11-001 ENSP00000264990 ENST00000264990	Q709F0 [Direct mapping] Acyl-CoA dehydrogenase family member 11 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0003995 [acyl-CoA dehydrogenase activity] GO:0004466 [long-chain-acyl-CoA dehydrogenase activity] GO:0005634 [nucleus] GO:0005743 [mitochondrial inner membrane] GO:0005777 [peroxisome] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0009055 [electron carrier activity] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0017099 [very-long-chain-acyl-CoA dehydrogenase activity] GO:0031966 [mitochondrial membrane] GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor] GO:0055088 [lipid homeostasis] GO:0055114 [oxidation-reduction process] GO:0070991 [medium-chain-acyl-CoA dehydrogenase activity] Show all	780 aa 87.3 kDa	No	0
ACAD11-005 ENSP00000420907 ENST00000481970	D6RDI8 [Direct mapping] Acyl-CoA dehydrogenase family member 11 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	476 aa 53.7 kDa	No	0