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Weak to moderate cytoplasmic and/or membranous staining was exhibited in several colorectal cancers along with a few cervical, endometrial, lung, testicular and urothelial cancers. Hodgkin's lymphomas showed moderate cytoplasmic and nuclear positivity. Remaining cancer tissues were mainly negative.
GENE INFORMATION
Gene name
TMEM189 (HGNC Symbol)
Synonyms
Kua
Description
Transmembrane protein 189 (HGNC Symbol)
Entrez gene summary
Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]