Expression of HLA-DOB in cancer - Summary

GENERAL INFORMATION
Gene name	HLA-DOB
Gene description	Major histocompatibility complex, class II, DO beta
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Daudi, U-698)
HPA (normal tissue):	Group enriched (lymph node, spleen, tonsil, urinary bladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a subset of lymphoid cells and secreted positivity in goblet cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA013846
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), ovarian cancer (favourable) and breast cancer (favourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA013846

GENE INFORMATION
Gene name	HLA-DOB
Synonyms
Description	Major histocompatibility complex, class II, DO beta (HGNC Symbol)
Entrez gene summary	HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.32
Chromosome location (bp)	32812763 - 32817048
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000241106 (version 83.38)
Entrez gene	3112
UniProt	P13765 (UniProt - Evidence at protein level)
neXtProt	NX_P13765
Antibodypedia	HLA-DOB antibodies

PROTEIN BROWSER

HLA-DOB-001	HLA-DOB-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HLA-DOB-001 ENSP00000390020 ENST00000438763	P13765 [Direct mapping] HLA class II histocompatibility antigen, DO beta chain Q5QNS2 [Target identity:100%; Query identity:100%] MHC class II antigen; Major histocompatibility complex, class II, DO beta, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0002587 [negative regulation of antigen processing and presentation of peptide antigen via MHC class II] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0023026 [MHC class II protein complex binding] GO:0032395 [MHC class II receptor activity] GO:0042613 [MHC class II protein complex] Show all	273 aa 30.8 kDa	Yes	1
HLA-DOB-004 ENSP00000394860 ENST00000447394	H0Y4X4 [Direct mapping] HLA class II histocompatibility antigen, DO beta chain Show all	Predicted intracellular proteins Show all	GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0042613 [MHC class II protein complex] Show all	182 aa 20.7 kDa	No	0