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CRCP

GENERAL INFORMATION

Gene name

 CRCP

Gene description

 CGRP receptor component

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA007216
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007216

GENE INFORMATION

Gene name

 CRCP (HGNC Symbol)

Synonyms

 CGRP-RCP, RCP, RCP9

Description

 CGRP receptor component (HGNC Symbol)

Entrez gene summary

 This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q11.21

Chromosome location (bp)

 66114604 - 66154568

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000241258 (version 83.38)

Entrez gene

 27297

UniProt

 O75575 (UniProt - Evidence at protein level)

neXtProt

 NX_O75575

Antibodypedia

 CRCP antibodies

PROTEIN BROWSER
CRCP-001
CRCP-003
CRCP-004
CRCP-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRCP-001
ENSP00000378736
ENST00000395326
O75575 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC9
A0A024RDL0 [Target identity:100%; Query identity:100%]
Calcitonin gene-related peptide-receptor component protein, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0001056 [RNA polymerase III activity]
GO:0001635 [calcitonin gene-related peptide receptor activity]
GO:0001669 [acrosomal vesicle]
GO:0003824 [catalytic activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006384 [transcription initiation from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0007218 [neuropeptide signaling pathway]
GO:0009360 [DNA polymerase III complex]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0044237 [cellular metabolic process]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
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 148 aa
16.9 kDa 		No 0
CRCP-003
ENSP00000388653
ENST00000431089
O75575 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC9
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001056 [RNA polymerase III activity]
GO:0003824 [catalytic activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006384 [transcription initiation from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0009360 [DNA polymerase III complex]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0044237 [cellular metabolic process]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
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 141 aa
15.6 kDa 		No 0
CRCP-004
ENSP00000340044
ENST00000338592
O75575 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC9
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001056 [RNA polymerase III activity]
GO:0003824 [catalytic activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006384 [transcription initiation from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0009360 [DNA polymerase III complex]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0044237 [cellular metabolic process]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
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 115 aa
13.1 kDa 		No 0
CRCP-005
ENSP00000381674
ENST00000398684
O75575 [Direct mapping]
DNA-directed RNA polymerase III subunit RPC9
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001056 [RNA polymerase III activity]
GO:0003824 [catalytic activity]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006384 [transcription initiation from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0009360 [DNA polymerase III complex]
GO:0010467 [gene expression]
GO:0032481 [positive regulation of type I interferon production]
GO:0044237 [cellular metabolic process]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
Show all
 71 aa
8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.