Cell atlas - CDRT1 - The Human Protein Atlas

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CDRT1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CDRT1
Gene description	CMT1A duplicated region transcript 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & nucleoli.
RNA cell category	Cell line enhanced (HaCaT, CAPAN-2)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleus (approved), Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA013332 , HPA047457
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT, CAPAN-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & nucleoli.

Main location

Nucleus (approved), Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA013332	A-431	Nucleus
HPA013332	A-431	Nucleoli
HPA013332	U-2 OS	Nucleus
HPA013332	U-2 OS	Nucleoli
HPA013332	U-251 MG	Nucleus
HPA013332	U-251 MG	Nucleoli
HPA047457	A549	Nucleoplasm
HPA047457	HeLa	Nucleoplasm
HPA047457	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	CDRT1 (HGNC Symbol)
Synonyms	FBXW10B, FBXW10P1, HREP, SM25H2
Description	CMT1A duplicated region transcript 1 (HGNC Symbol)
Entrez gene summary	Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Chromosome	17
Cytoband	p12
Chromosome location (bp)	15565483 - 15619704
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000241322 (version 83.38)
Entrez gene	374286
UniProt	O95170 (UniProt - Evidence at transcript level)
neXtProt	NX_O95170
Antibodypedia	CDRT1 antibodies

PROTEIN BROWSER

CDRT1-001	CDRT1-003	CDRT1-005	CDRT1-007	CDRT1-009	CDRT1-201	CDRT1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDRT1-001 ENSP00000346416 ENST00000354433	O95170 [Direct mapping] CMT1A duplicated region transcript 1 protein Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	252 aa 27.6 kDa	No	0
CDRT1-003 ENSP00000468137 ENST00000472534	K7ER72 [Direct mapping] CMT1A duplicated region transcript 1 protein Show all	Predicted intracellular proteins Show all		70 aa 7.9 kDa	No	0
CDRT1-005 ENSP00000462959 ENST00000583965	J3KTF7 [Direct mapping] CMT1A duplicated region transcript 1 protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	78 aa 8.9 kDa	No	0
CDRT1-007 ENSP00000379242 ENST00000395906	O95170 [Direct mapping] CMT1A duplicated region transcript 1 protein Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	752 aa 85.4 kDa	No	0
CDRT1-009 ENSP00000261644 ENST00000261644	I3L073 [Direct mapping] CMT1A duplicated region transcript 1 protein Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	301 aa 34.2 kDa	No	0
CDRT1-201 ENSP00000379026 ENST00000395667	A0A087WSX6 [Direct mapping] CMT1A duplicated region transcript 1 protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	714 aa 82.1 kDa	No	0
CDRT1-202 ENSP00000486674 ENST00000630868	Q9BXD7 [Direct mapping] CMT duplicated region transcript 1; CMT1A duplicated region transcript 1 protein Show all	Predicted intracellular proteins Show all		243 aa 27.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.