Expression of EGFL8 in cancer - Summary - The Human Protein Atlas

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EGFL8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EGFL8
Gene description	EGF-like-domain, multiple 8
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in connective tissue.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA061173
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA061173

GENE INFORMATION
Gene name	EGFL8 (HGNC Symbol)
Synonyms	C6orf8, NG3
Description	EGF-like-domain, multiple 8 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p21.32
Chromosome location (bp)	32164583 - 32168281
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000241404 (version 83.38)
Entrez gene	80864
UniProt	Q99944 (UniProt - Evidence at protein level)
neXtProt	NX_Q99944
Antibodypedia	EGFL8 antibodies

PROTEIN BROWSER

EGFL8-001	EGFL8-002	EGFL8-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EGFL8-001 ENSP00000378888 ENST00000395512	Q99944 [Direct mapping] Epidermal growth factor-like protein 8 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	293 aa 32.3 kDa	Yes	0
EGFL8-002 ENSP00000333380 ENST00000333845	Q99944 [Direct mapping] Epidermal growth factor-like protein 8 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	293 aa 32.3 kDa	Yes	0
EGFL8-004 ENSP00000401694 ENST00000432129	Q5JP22 [Direct mapping] Epidermal growth factor-like protein 8 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	258 aa 28.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.