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ARPC1A

GENERAL INFORMATION

Gene name

 ARPC1A

Gene description

 Actin related protein 2/3 complex, subunit 1A, 41kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic and membranous expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA004334
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARPC1A (HGNC Symbol)

Synonyms

 Arc40, SOP2Hs, SOP2L

Description

 Actin related protein 2/3 complex, subunit 1A, 41kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 99325898 - 99388164

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000241685 (version 83.38)

Entrez gene

 10552

UniProt

 Q92747 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92747

Antibodypedia

 ARPC1A antibodies

PROTEIN BROWSER
ARPC1A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARPC1A-001
ENSP00000262942
ENST00000262942
Q92747 [Direct mapping]
Actin-related protein 2/3 complex subunit 1A
V9HVZ6 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 68
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005885 [Arp2/3 protein complex]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0015629 [actin cytoskeleton]
GO:0030036 [actin cytoskeleton organization]
GO:0030833 [regulation of actin filament polymerization]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0036195 [muscle cell projection membrane]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
Show all
 370 aa
41.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.