Expression of TMEFF1 in cancer - Summary - The Human Protein Atlas

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TMEFF1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEFF1
Gene description	Transmembrane protein with EGF-like and two follistatin-like domains 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (ovarian cancer)
HPA (cell line):	Cell line enhanced (NTERA-2, REH, SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. RNA data suggests low expression in CNS.
Reliability score	Uncertain based on 1 antibody. HPA051501
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (ovarian cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051501

GENE INFORMATION
Gene name	TMEFF1 (HGNC Symbol)
Synonyms	C9orf2, CT120.1, H7365
Description	Transmembrane protein with EGF-like and two follistatin-like domains 1 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q31.1
Chromosome location (bp)	100473113 - 100577636
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000241697 (version 83.38)
Entrez gene	8577
UniProt	Q8IYR6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IYR6
Antibodypedia	TMEFF1 antibodies

PROTEIN BROWSER

TMEFF1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEFF1-001 ENSP00000364013 ENST00000374879	Q8IYR6 [Direct mapping] Tomoregulin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] Show all	380 aa 40.9 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.