Expression of HOGA1 in cancer - Summary - The Human Protein Atlas

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HOGA1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HOGA1
Gene description	4-hydroxy-2-oxoglutarate aldolase 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (liver cancer, renal cancer)
HPA (cell line):	Cell line enhanced (EFO-21, Hep G2, RPTEC TERT1)
HPA (normal tissue):	Tissue enhanced (kidney, liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including kidney and liver.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA039466
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (liver cancer, renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039466

GENE INFORMATION
Gene name	HOGA1 (HGNC Symbol)
Synonyms	C10orf65, DHDPS2, DHDPSL, FLJ37472, NPL2
Description	4-hydroxy-2-oxoglutarate aldolase 1 (HGNC Symbol)
Entrez gene summary	The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]
Chromosome	10
Cytoband	q24.2
Chromosome location (bp)	97584323 - 97612802
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000241935 (version 83.38)
Entrez gene	112817
UniProt	Q86XE5 (UniProt - Evidence at protein level)
neXtProt	NX_Q86XE5
Antibodypedia	HOGA1 antibodies

PROTEIN BROWSER

HOGA1-001	HOGA1-003	HOGA1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HOGA1-001 ENSP00000359681 ENST00000370647	Q86XE5 [Direct mapping] 4-hydroxy-2-oxoglutarate aldolase, mitochondrial Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0008700 [4-hydroxy-2-oxoglutarate aldolase activity] GO:0009436 [glyoxylate catabolic process] GO:0016829 [lyase activity] GO:0019470 [4-hydroxyproline catabolic process] GO:0033609 [oxalate metabolic process] GO:0042803 [protein homodimerization activity] GO:0042866 [pyruvate biosynthetic process] GO:0046487 [glyoxylate metabolic process] GO:0070062 [extracellular exosome] Show all	164 aa 18 kDa	No	0
HOGA1-003 ENSP00000359680 ENST00000370646	Q86XE5 [Direct mapping] 4-hydroxy-2-oxoglutarate aldolase, mitochondrial Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0008700 [4-hydroxy-2-oxoglutarate aldolase activity] GO:0009436 [glyoxylate catabolic process] GO:0016829 [lyase activity] GO:0019470 [4-hydroxyproline catabolic process] GO:0033609 [oxalate metabolic process] GO:0042803 [protein homodimerization activity] GO:0042866 [pyruvate biosynthetic process] GO:0046487 [glyoxylate metabolic process] GO:0070062 [extracellular exosome] Show all	327 aa 35.2 kDa	No	0
HOGA1-004 ENSP00000359676 ENST00000370642	H7BY76 [Direct mapping] 4-hydroxy-2-oxoglutarate aldolase, mitochondrial Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016829 [lyase activity] Show all	85 aa 8.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.